PARTIAL COMPLEMENT DEFICIENCIES IN IDIOPATHIC THROMBOCYTOPENIA OF CHILDHOOD

被引：4

作者：

NIELSEN, HE

TRUEDSSON, L

DONNER, M

机构：

[1] LUND UNIV,DEPT MED MICROBIOL,LUND,SWEDEN

[2] LUND UNIV,DEPT PAEDIAT,LUND,SWEDEN

[3] RIGSHOSP,DEPT PAEDIAT,COPENHAGEN,DENMARK

[4] STATENS SERUM INST,COMPLEMENT LAB,COPENHAGEN,DENMARK

来源：

ACTA PAEDIATRICA | 1994年 / 83卷 / 07期

关键词：

CHILDREN; COMPLEMENT C2; C4; BF; COMPLEMENT ALLOTYPES; COMPLEMENT DEFICIENCY; IDIOPATHIC THROMBOCYTOPENIA;

D O I：

10.1111/j.1651-2227.1994.tb13132.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We have examined the classical complement activation pathway in 36 children with idiopathic thrombocytopenia (ITP) in a retrospective study. An increased prevalence of congenital, partial complement deficiencies is found in ITP. Homozygous C4A deficiency was found in 5 patients (p < 0.05) and heterozygous C2 deficiency in 2 other patients (p = 0.05). We suggest that some cases of childhood ITP belong to the immune complex mediated diseases, such as systemic lupus erythematosus and that abnormal immune complex formation and clearance may lead to ITP.

引用

页码：749 / 753

页数：5

共 29 条

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