SYNTHESIS OF 4,5,6,7-TETRAHYDRO-1(3H)-ISOBENZOFURANONES BY REACTION OF N,N-DIMETHYL-2-LITHIO-1-CYCLOHEXENECARBOXAMIDE WITH ALDEHYDES AND KETONES

被引:33
作者
BAKER, WR [1 ]
COATES, RM [1 ]
机构
[1] UNIV ILLINOIS,DEPT CHEM,URBANA,IL 61801
关键词
D O I
10.1021/jo01320a037
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The frequent occurrence of α, β-unsaturated γ-lactones in many types of natural products has stimulated considerable interest in the synthesis of Δαβ-butenolides.1 Although a great variety of synthetic routes to these compounds may be found in the literature, there appear to be few reports of syntheses of bicyclic Δαβ-butenolides with a carbocycle fused across the α and β positions, such as 4, 5, 6, 7-tetrahydro-l(3H)-isobenzofuranones (5). © 1979, American Chemical Society. All rights reserved.
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页码:1022 / 1024
页数:3
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