HISTAMINE-RELEASE BY PLATELET-AGGREGATION

被引：17

作者：

MANNAIONI, PF ^{[1
]}

PALMERANI, B ^{[1
]}

PISTELLI, A ^{[1
]}

GAMBASSI, F ^{[1
]}

GIANNELLA, E ^{[1
]}

SACCHI, TB ^{[1
]}

MASINI, E ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT HUMAN ANAT & HISTOL,HISTOL SECT,I-50134 FLORENCE,ITALY

来源：

AGENTS AND ACTIONS | 1990年 / 30卷 / 1-2期

关键词：

D O I：

10.1007/BF01968994

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coincubation of rat serosal mast cells with human platelets leads to a significant release of histamine, which dose-dependently increases when platelet aggregation is induced by various concentrations of arachidonic acid. In turn, histamine enhances platelet aggregation induced by different agonists, this effect being mimicked by pyridyl-ethyl-amine (PEA), blocked by mepyramine and amplified by ranitidine. The data suggest the existence of a platelet-derived histamine releasing factor (PDHRF) and indicate the presence of platelet H1 and H2 receptors, capable of modulating platelet aggregation. © 1990 Birkhäuser Verlag.

引用

页码：44 / 48

页数：5

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