SYNTHESIS OF DES-N-METHYLACRONYCINE AND ACRONYCINE

被引：23

作者：

LOUGHHEAD, DG

机构：

[1] Syntex Research, Institute of Organic Chemistry, Palo Alto, California 94304

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 07期

关键词：

D O I：

10.1021/jo00294a052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Des-N-methylacronycine (3) and acronycine (4) are closely related acridine alkaloids which have been isolated from a variety of plant sources.2,3 Acronycine in particular has attracted attention because it has demonstrated antitumor activity in experimental animals4 and has been evaluated in human patients with multiple myeloma.5 We had interest in preparing des-N-methylacronycine since this compound could serve as an intermediate for the preparation of several N-substituted analogues, including acronycine itself6. © 1990, American Chemical Society. All rights reserved.

引用

页码：2245 / 2246

页数：2

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