NALOXONE ENHANCES THE RELEASE OF ACETYLCHOLINE FROM CHOLINERGIC INTERNEURONS OF THE STRIATUM IF THE DOPAMINERGIC INPUT IS IMPAIRED

被引：13

作者：

SANDOR, NT ^{[1
]}

KISS, J ^{[1
]}

SANDOR, A ^{[1
]}

LENDVAI, B ^{[1
]}

VIZI, ES ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,INST EXPTL MED,POB 67,H-1450 BUDAPEST,HUNGARY

来源：

BRAIN RESEARCH | 1991年 / 552卷 / 02期

关键词：

RAT STRIATUM; ACETYLCHOLINE RELEASE; DOPAMINERGIC CONTROL; OPIATE RECEPTOR; NALOXONE; PRESYNAPTIC MODULATION;

D O I：

10.1016/0006-8993(91)90102-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Naloxone significantly enhanced the release of radioactive acetylcholine ([H-3]ACh) from rat striatal slices loaded with [H-3]choline either when the nigrostriatal pathway had been destroyed by 6-hydroxydopamine or when the D2 dopamine receptors had been inhibited by sulpiride. This in vitro study supplies the first neurochemical evidence, that, in addition to D2-receptor-mediated dopaminergic tonic control, there is opiate-receptor mediated presynaptic modulation of striatal ACh release, possibly by endogenous enkephalin released from local neurons. Such modulation occurs under conditions in which the dopaminergic input is impaired.

引用

页码：343 / 345

页数：3

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