STUDIES ON THE PROTECTIVE EFFECTS OF ASCORBIC-ACID IN RUBIDIUM TOXICITY

被引：11

作者：

CHATTERJEE, GC ^{[1
]}

CHATTERJEE, S ^{[1
]}

CHATTERJEE, K ^{[1
]}

SAHU, A ^{[1
]}

BHATTACHARYYA, A ^{[1
]}

CHAKRABORTY, D ^{[1
]}

DAS, PK ^{[1
]}

机构：

[1] UNIV CALCUTTA,DEPT ZOOL,HISTOPATHOL LAB,CALCUTTA 700019,W BENGAL,INDIA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1979年 / 51卷 / 01期

关键词：

D O I：

10.1016/0041-008X(79)90007-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Studies have been carried out on the effects of subacute rubidium chloride toxicity in rats in relation to l-ascorbic acid metabolism and certain enzymes of liver, kidney, and brain tissues as well as hepatic lipid composition. Rubidium-treated (ip) rats showed drastic decrease in growth along with a severe anemic condition which could not be reversed by oral l-ascorbic acid supplementation. Rudidium toxicity markedly disturbed the normal histological pattern of both liver and kidney cells and also significantly changed the hepatic lipid composition. Brain tissue was found to be affected severely as showed by certain enzyme activity alterations. l-Ascorbic acid supplementation to the treated group of animals could afford some protection against the alterations of certain liver enzymes as well as in regard to the histological changes of either liver and kidney as caused by rubidium toxicity. © 1979.

引用

页码：47 / 58

页数：12

共 34 条

[1]

ALEXANDER GJ, 1975, J PHARMACOL EXP THER, V194, P480

[2] EFFECT OF THYROID-DEFICIENCY ON LEVELS OF SEVERAL ENZYMES IN RAT-BRAIN [J].

BERA, H ;

CHATTERJEE, GC .

JOURNAL OF NEUROCHEMISTRY, 1975, 24 (05) :859-863

[3]

CHAKRABORTY D, 1978, INT J VITAM NUTR RES, V48, P22

[4]

CHAKRABORTY D, 1977, INT J VITAM NUTR RES, V47, P81

[5] STUDIES ON L-ASCORBIC-ACID METABOLISM IN RATS UNDER CHRONIC TOXICITY DUE TO ORGANOPHOSPHORUS INSECTICIDES - EFFECTS OF SUPPLEMENTATION OF L-ASCORBIC-ACID IN HIGH DOSES [J].

CHAKRABORTY, D ;

BHATTACHARYYA, A ;

MAJUMDAR, K ;

CHATTERJEE, K ;

CHATTERJEE, S ;

SEN, A ;

CHATTERJEE, GC .

JOURNAL OF NUTRITION, 1978, 108 (06) :973-980

[6]

CHATTERJEE GC, 1973, INT J VITAM NUTR RES, V43, P370

[7] EFFECT OF CHROMIUM AND TUNGSTEN ON L-ASCORBIC-ACID METABOLISM IN RATS AND CHICKS [J].

CHATTERJEE, GC ;

ROY, RK ;

SASMAL, N ;

BANERJEE, SK ;

MAJUMDER, PK .

JOURNAL OF NUTRITION, 1973, 103 (04) :509-514

[8]

CHATTERJEE GC, 1975, INT J VITAM NUTR RES, V45, P284

[9]

CURRAN GL, 1954, J BIOL CHEM, V210, P765

[10] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

← 1 2 3 4 →