SYNTHESIS OF A 6-O-PHOSPHORYLATED ANALOG OF THE ANTITHROMBIN-III BINDING SEQUENCE OF HEPARIN - REPLACEMENT OF ONE ESSENTIAL SULFATE GROUP BY A PHOSPHATE GROUP NULLIFIES THE BIOLOGICAL-ACTIVITY

被引：10

作者：

VOS, JN

WESTERDUIN, P

VANBOECKEL, CAA

机构：

[1] Akzo Pharma Division, Organon Scientific Development Group, 5340 BH Oss

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)80786-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of an analogue (i.e. compound 7) of the AT-III binding sequence of heparin is described in which an essential 6-O-SO3 group at the non-reducing glucosamine is replaced by a phosphate group. This compound appears to be biologically inactive.

引用

页码：143 / 146

页数：4

共 14 条

[1]

Choay J, 1981, Ann N Y Acad Sci, V370, P644, DOI 10.1111/j.1749-6632.1981.tb29770.x

[2]

GROOTENHUIS PDJ, IN PRESS J AM CHEM S

[3] HIGH SPECIFICITY OF A PHOSPHATE-TRANSPORT PROTEIN DETERMINED BY HYDROGEN-BONDS [J].