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GUIDELINES FOR THE WELFARE OF ANIMALS IN RODENT PROTECTION TESTS
被引：28
作者：
ACRED, P
HENNESSEY, TD
MACARTHURCLARK, JA
MERRIKIN, DJ
RYAN, DM
SMULDERS, HC
TROKE, PF
WILSON, RG
STRAUGHAN, DW
机构：
[1] PFIZER LTD,SANDWICH CT13 9NJ,KENT,ENGLAND
[2] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND
[3] ZENECA PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
[4] JMC CONSULTANCY,SANDWICH CT13 9DU,KENT,ENGLAND
[5] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND
[6] HOME OFF,SHREWSBURY SY3 7NR,ENGLAND
关键词：
RODENT PROTECTION TEST;
ANIMAL WELFARE;
HUMANE END POINTS;
CLINICAL ASSESSMENT;
EUTHANASIA;
D O I：
10.1258/002367794781065870
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The rodent protection test (RPT) is used in antimicrobial research to confirm the in vivo efficacy of novel antibacterial, antiviral and antifungal agents. The RPT may involve lethal infection and thus has the potential to cause significant suffering. These Guidelines recommend refinements to the RPT which reduce animal use to a minimum and suggest cardinal clinical signs which act as predictors of lethality. Early recognition of these signs is imperative to minimize suffering, allow identification of humane end points and permit timely euthanasia. Constructive suggestions for the improvement of these Guidelines are welcomed.
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页码：13 / 18
页数：6
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