2 UROKINASE DOSE REGIMENS IN NATIVE ARTERIAL AND GRAFT OCCLUSIONS - INITIAL RESULTS OF A PROSPECTIVE, RANDOMIZED CLINICAL-TRIAL

被引:52
作者
CRAGG, AH
SMITH, TP
CORSON, JD
NAKAGAWA, N
CASTANEDA, F
KRESOWIK, TF
SHARP, WJ
SHAMMA, A
BERBAUM, KS
机构
[1] UNIV IOWA, COLL MED, DEPT RADIOL, IOWA CITY, IA 52242 USA
[2] UNIV IOWA, COLL MED, DEPT SURG, IOWA CITY, IA 52242 USA
关键词
ARTERIES; EXTREMITIES; STENOSIS OR OBSTRUCTION; TRANSLUMINAL ANGIOPLASTY; THROMBOLYSIS; THROMBOSIS; ARTERIAL; UROKINASE;
D O I
10.1148/radiology.178.3.1994402
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The effects of two urokinase (UK) dose regimens on lysis time, lytic success, primary clinical success, and frequency of complications of peripheral thrombolysis were compared. Seventy-two intraarterial UK infusions were performed by means of standard catheter-directed infusion techniques in 63 patients with symptomatic peripheral arterial or bypass graft occlusions. Patients were prospectively randomized to high-dose (250,000 U/h for 4 hours and then 125,000 U/h) or low-dose (50,000 U/h) regimens. The mean time to complete lysis was 20.8, 26.0, 16.5, and 18.2 hours for the high-dose artery, low-dose artery, high-dose graft, and low-dose graft groups, respectively (P was not significant). Respective mean infusion durations were 27.1, 35.4, 22.2, and 25.3 hours. Clinical success was achieved in 65%-85% of cases. The frequency of complications was equivalent between groups, except for a higher frequency of minor bleeding complications in the high-dose group. The two urokinase dose regimens studied were equally effective in enabling peripheral thrombolysis.
引用
收藏
页码:681 / 686
页数:6
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