ENANTIOSPECIFIC ANALYSIS OF KETOPROFEN IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：26

作者：

HAYBALL, PJ

NATION, RL

BOCHNER, F

LELEU, RK

机构：

[1] UNIV ADELAIDE,DEPT CLIN & EXPTL PHARMACOL,ADELAIDE,SA 5000,AUSTRALIA

[2] UNIV S AUSTRALIA,SCH PHARM,ADELAIDE,SA 5000,AUSTRALIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 570卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0378-4347(91)80552-N

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic (HPLC) assay for the determination of the R- and S-enantiomers of ketoprofen is described. Facile ketoprofen extraction from plasma and derivatization to the diastereomeric S-1-phenylethylamides was followed by normal-phase HPLC. The ketoprofen diastereomeric amides eluted within 8 min. The limit of quantification of the assay was 0.15 mg/l of each enantiomer (signal-to-noise ratio = 5).

引用

页码：446 / 452

页数：7

共 9 条

[1] DETERMINATION OF THE ENANTIOMERS OF KETOPROFEN IN BLOOD-PLASMA BY ION-PAIR EXTRACTION AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF LEUCINAMIDE DERIVATIVES
BJORKMAN, S
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 414 (02): : 465 - 471
[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY OF KETOPROFEN ENANTIOMERS IN HUMAN-PLASMA AND URINE
FOSTER, RT
JAMALI, F
[J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 416 (02): : 388 - 393
[3] HAMON DPG, UNPUB J LABELLED COM
[4] THE METABOLIC CHIRAL INVERSION OF 2-ARYLPROPIONIC ACIDS - A NOVEL ROUTE WITH PHARMACOLOGICAL CONSEQUENCES
HUTT, AJ
CALDWELL, J
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1983, 35 (11) : 693 - 704
[5] CLINICAL PHARMACOKINETICS OF KETOPROFEN AND ITS ENANTIOMERS
JAMALI, F
BROCKS, DR
[J]. CLINICAL PHARMACOKINETICS, 1990, 19 (03) : 197 - 217
[6] TOTAL AND FREE KETOPROFEN IN SERUM AND SYNOVIAL-FLUID AFTER INTRAMUSCULAR INJECTION
NETTER, P
BANNWARTH, B
LAPICQUE, F
HARREWYN, JM
FRYDMAN, A
TAMISIER, JN
GAUCHER, A
ROYER, RJ
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 42 (05) : 555 - 561
[7] ROYER RJ, 1986, BIOMED PHARMACOTHER, V40, P100
[8] ENANTIOSPECIFIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF 2-PHENYLPROPIONIC ACID, KETOPROFEN AND FENOPROFEN
SALLUSTIO, BC
ABAS, A
HAYBALL, PJ
PURDIE, YJ
MEFFIN, PJ
[J]. JOURNAL OF CHROMATOGRAPHY, 1986, 374 (02): : 329 - 337
[9] CONVENIENT AND SENSITIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ASSAY FOR KETOPROFEN, NAPROXEN AND OTHER ALLIED DRUGS IN PLASMA OR URINE
UPTON, RA
BUSKIN, JN
GUENTERT, TW
WILLIAMS, RL
RIEGELMAN, S
[J]. JOURNAL OF CHROMATOGRAPHY, 1980, 190 (01): : 119 - 128

← 1 →