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RECOMBINANT TOXINS FOR CANCER-TREATMENT

被引：287
作者：
PASTAN, I
FITZGERALD, D
机构：
[1] Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, National Institutes of Health, Bethesda
来源：
SCIENCE | 1991年 / 254卷 / 5035期
关键词：
D O I：
10.1126/science.1683495
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Recombinant toxins target cell surface receptors and antigens on tumor cells. They kill by mechanisms different from conventional chemotherapy, so that cross resistance to conventional chemotherapeutic agents should not be a problem. Furthermore, they are not mutagens and should not induce secondary malignancies or accelerate progression of benign malignancies. They can be mass-produced cheaply in bacteria as homogeneous proteins. Either growth factor-toxin fusions or antibody-toxin fusions can be chosen, depending on the cellular target.
引用
收藏
页码：1173 / 1177
页数：5
相关论文
共 91 条
  • [1] STRUCTURE OF EXOTOXIN-A OF PSEUDOMONAS-AERUGINOSA AT 3.0-ANGSTROM RESOLUTION
    ALLURED, VS
    COLLIER, RJ
    CARROLL, SF
    MCKAY, DB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (05) : 1320 - 1324
  • [2] ANTITUMOR-ACTIVITY IN MICE OF AN IMMUNOTOXIN MADE WITH ANTI-TRANSFERRIN RECEPTOR AND A RECOMBINANT FORM OF PSEUDOMONAS EXOTOXIN
    BATRA, JK
    JINNO, Y
    CHAUDHARY, VK
    KONDO, T
    WILLINGHAM, MC
    FITZGERALD, DJ
    PASTAN, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) : 8545 - 8549
  • [3] SINGLE-CHAIN IMMUNOTOXINS DIRECTED AT THE HUMAN TRANSFERRIN RECEPTOR CONTAINING PSEUDOMONAS EXOTOXIN-A OR DIPHTHERIA-TOXIN - ANTI-TFR(FV)-PE40 AND DT388-ANTI-TFR(FV)
    BATRA, JK
    FITZGERALD, DJ
    CHAUDHARY, VK
    PASTAN, I
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (04) : 2200 - 2205
  • [4] SINGLE-CHAIN ANTIGEN-BINDING PROTEINS
    BIRD, RE
    HARDMAN, KD
    JACOBSON, JW
    JOHNSON, S
    KAUFMAN, BM
    LEE, SM
    LEE, T
    POPE, SH
    RIORDAN, GS
    WHITLOW, M
    [J]. SCIENCE, 1988, 242 (4877) : 423 - 426
  • [5] IMMUNOTOXINS - HYBRID MOLECULES OF MONOCLONAL-ANTIBODIES AND A TOXIN SUBUNIT SPECIFICALLY KILL TUMOR-CELLS
    BLYTHMAN, HE
    CASELLAS, P
    GROS, O
    GROS, P
    JANSEN, FK
    PAOLUCCI, F
    PAU, B
    VIDAL, H
    [J]. NATURE, 1981, 290 (5802) : 145 - 146
  • [6] B3(FV)-PE38KDEL, A SINGLE-CHAIN IMMUNOTOXIN THAT CAUSES COMPLETE REGRESSION OF A HUMAN CARCINOMA IN MICE
    BRINKMANN, U
    PAI, LH
    FITZGERALD, DJ
    WILLINGHAM, M
    PASTAN, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) : 8616 - 8620
  • [7] BYERS VS, 1989, CANCER RES, V49, P6153
  • [8] A RAPID METHOD OF CLONING FUNCTIONAL VARIABLE-REGION ANTIBODY GENES IN ESCHERICHIA-COLI AS SINGLE-CHAIN IMMUNOTOXINS
    CHAUDHARY, VK
    BATRA, JK
    GALLO, MG
    WILLINGHAM, MC
    FITZGERALD, DJ
    PASTAN, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (03) : 1066 - 1070
  • [9] A RECOMBINANT SINGLE-CHAIN IMMUNOTOXIN COMPOSED OF ANTI-TAC VARIABLE REGIONS AND A TRUNCATED DIPHTHERIA-TOXIN
    CHAUDHARY, VK
    GALLO, MG
    FITZGERALD, DJ
    PASTAN, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (23) : 9491 - 9494
  • [10] A RECOMBINANT IMMUNOTOXIN CONSISTING OF 2 ANTIBODY VARIABLE DOMAINS FUSED TO PSEUDOMONAS EXOTOXIN
    CHAUDHARY, VK
    QUEEN, C
    JUNGHANS, RP
    WALDMANN, TA
    FITZGERALD, DJ
    PASTAN, I
    [J]. NATURE, 1989, 339 (6223) : 394 - 397
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