MEASUREMENT OF ABSOLUTE BLOOD IODINE CONCENTRATION DURING DIGITAL SUBTRACTION VENTRICULOGRAPHY

被引:1
作者
FUERST, TP [1 ]
VANLYSEL, MS [1 ]
机构
[1] UNIV WISCONSIN,SCH MED,DEPT MED PHYS,MADISON,WI 53792
关键词
BLOOD IODINE CONCENTRATION; DIGITAL SUBTRACTION ANGIOGRAPHY (DSA); VIDEODENSITOMETRY; VOLUME MEASUREMENT; INDICATOR-DILUTION TECHNIQUES;
D O I
10.1118/1.596985
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
A system to measure the absolute iodine concentration (mg iodine/milliliter blood) in the left ventricle (LV) during digital subtraction ventriculography has been developed. The technique uses a catheter to draw blood from the LV through a detection cell. This occurs as the iodine bolus passes through the heart. The cell determines iodine concentration by measuring x-ray attenuation as the iodinated blood passes between a low-power x-ray tube and a diode detector. In vitro and in vivo testing of the system was conducted. The system response was linear (r = 0.99) with respect to iodine concentration. This response was independent of hematocrit. Dispersion of contrast medium in the catheter caused distortion of the shape of the time-concentration curve. The impulse response of the system was measured and found to be independent of hematocrit. A correction algorithm based on Wiener filter deconvolution was developed. In vitro testing using simulated time-concentration curves demonstrated that the rms error in the iodine measurement after dispersion correction did not exceed 4% over the region of the time-concentration curve extending from the peak to the point on the tail where the signal fell to 50% of its peak value. Cardiac output was measured from the time-concentration curve via the indicator-dilution method in an animal model. This cardiac output measurement (CO(I)) agreed closely with cardiac output measured simultaneously with an aortic flow probe (CO(P)), namely, CO(I) = 1.02 CO(P)-0.03 L/min, r = 0.95, SEE = 10%, p < 0.001. The application of the blood iodine concentration measurement to the densitometric measurement of absolute LV volume from digital subtraction angiography (DSA) images is discussed.
引用
收藏
页码:795 / 803
页数:9
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