TREATMENT OF NEUROTOXIC SIDE-EFFECTS OF INTERFERON-ALPHA WITH NALTREXONE

被引：79

作者：

VALENTINE, AD ^{[1
]}

MEYERS, CA ^{[1
]}

TALPAZ, M ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CLIN INVEST,HOUSTON,TX 77030

来源：

CANCER INVESTIGATION | 1995年 / 13卷 / 06期

关键词：

D O I：

10.3109/07357909509024923

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interferon-alpha (IFN-alpha) has potential dose-limiting neurotoxic side effects when used in cancer therapy. The nature of this neurotoxicity is speculative, and there is no definitive treatment. Because animal studies suggest that IFN-alpha acts at opioid receptor sites, we save naltrexone, a long-acting opioid antagonist, to 9 patients who had hematological malignancies and who suffered from IFN-alpha side effects. Seven of these patients experienced complete or moderate relief of side effects. Five of the patients rested before and during naltrexone treatment showed improvement of cognitive functioning. Two patients could not tolerate naltrexone side effects. This study suggests an intervention against IFN-alpha side effects and provides support for the role of opioid receptor interaction in IFN-alpha neurotoxicity.

引用

页码：561 / 566

页数：6

共 19 条

[1] NEUROPSYCHIATRIC MANIFESTATIONS OF HUMAN-LEUKOCYTE INTERFERON THERAPY IN PATIENTS WITH CANCER
ADAMS, F
QUESADA, JR
GUTTERMAN, JU
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1984, 252 (07): : 938 - 941
[2] ALPHA-INTERFERON MODIFIES CORTICAL EEG ACTIVITY - DOSE-DEPENDENCE AND ANTAGONISM BY NALOXONE
BIRMANNS, B
SAPHIER, D
ABRAMSKY, O
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1990, 100 (1-2) : 22 - 26
[3] HUMAN-LEUKOCYTE INTERFERON (HUIFN-ALPHA) - POTENT ENDORPHIN-LIKE OPIOID ACTIVITY
BLALOCK, JE
SMITH, EM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 101 (02) : 472 - 478
[4] BLALOCK JE, 1980, P NATL ACAD SCI USA, V77, P5922
[5] SINGLE INJECTION OF 3 DIFFERENT PREPARATIONS OF ALPHA-INTERFERON MODIFIES MORPHINE ABSTINENCE SIGNS FOR A PROLONGED PERIOD
DAFNY, N
REYESVAZQUEZ, C
[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1987, 32 (3-4) : 953 - 961
[6] DOES THE IMMUNE SYSTEM COMMUNICATE WITH THE CENTRAL NERVOUS-SYSTEM - INTERFERON MODIFIES CENTRAL NERVOUS ACTIVITY
DAFNY, N
PRIETOGOMEZ, B
REYESVAZQUEZ, C
[J]. JOURNAL OF NEUROIMMUNOLOGY, 1985, 9 (1-2) : 1 - 12
[7] BEHAVIORAL AND ECOG SPECTRUM CHANGES INDUCED BY INTRACEREBRAL INFUSION OF INTERFERONS AND INTERLEUKIN-2 IN RATS ARE ANTAGONIZED BY NALOXONE
DESARRO, GB
MASUDA, Y
ASCIOTI, C
AUDINO, MG
NISTICO, G
[J]. NEUROPHARMACOLOGY, 1990, 29 (02) : 167 - +
[8] IIVANAINEN M, 1985, ACTA NEUROL SCAND, V72, P475
[9] MATTSON K, 1983, CANCER TREAT REP, V67, P958
[10] Meyers C. A., 1993, Proceedings of the American Association for Cancer Research Annual Meeting, V34, P218

← 1 2 →