TRICARBONYL ETA-16 ARENE CHROMIUM(0) BASED ANTITUMOR AGENTS

被引：20

作者：

JONES, GB

MATHEWS, JE

机构：

[1] Department of Chemistry, Clemson University, Clemson

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/0960-894X(94)00465-R

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel arene chromium carbonyl complexed mustard agents have been prepared. The metal carbonyl group modulates mustard alkylative ability as evidenced by 4-NBP assay. Antitumor evaluation against the human colon tumor line HCT-116 however showed no clear correlation between alkylative ability and antitumor activity of the mustard agents, in part a consequence of the inherent cytotoxicity of the metal carbonyl group in this screen.

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页码：93 / 96

页数：4

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