AN ACID LABILE ARGININE DERIVATIVE FOR PEPTIDE-SYNTHESIS - N(G)-2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL-L-ARGININE

被引：53

作者：

RAMAGE, R

GREEN, J

BLAKE, AJ

机构：

[1] Department of Chemistry, University of Edinburgh, Edinburgh, EH9 3JJ, West Mains Road

来源：

TETRAHEDRON | 1991年 / 47卷 / 32期

关键词：

D O I：

10.1016/S0040-4020(01)86564-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A trifluoroacetic acid (TFA) labile protecting group for the guanidine side chain function of arginine has been developed. N(G)-(2,2,5,7,8-Pentamethylchroman-6-sulphonyl-L-arginine is cleaved rapidly in TFA or 50% TFA in dichloromethane at room temperature. The preparations of Fmoc.Arg(Pmc).OH and Bnpeoc.Arg(Pmc).OH are described.

引用

页码：6353 / 6370

页数：18

共 27 条

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