PROSTAGLANDIN-E ANTAGONIST ACTIVITY OF 11-DEOXY-16, 16-TRIMETHYLENEPROSTAGLANDIN-E1

被引：3

作者：

BIRNBAUM, JE

TOLMAN, EL

机构：

[1] Biological Research Dept. Metabolic Disease Research Section Medical Research Div. American Cyanamid, Pearl River

来源：

PROSTAGLANDINS | 1979年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0090-6980(79)80053-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

11-Deoxy-16,16-trimethyleneprostaglandin E1 is a potent inhibitor of prostaglandin E-induced contractions of the gerbil colon. The antagonism is directed specifically against the prostaglandin E receptor and is not manifested when contractions are induced by either prostaglandin F2α or acetylcholine. © 1979.

引用

页码：349 / 357

页数：9

共 4 条

[1]

Ramwell P W, 1970, Recent Prog Horm Res, V26, P139

[2]

SANNER JH, 1976, PROSTAGLANDINS CHEM, P139

[3] PROSTAGLANDINS AND CONGENERS .14. SYNTHESIS AND BRONCHODILATOR ACTIVITY OF "DL-16,16-TRIMETHYLENEPROSTAGLANDINS [J].

SKOTNICKI, JS ;

SCHAUB, RE ;

WEISS, MJ ;

DESSY, F .

JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (08) :1042-1047

[4] PROSTAGLANDIN-E ANTAGONIST ACTIVITY OF 11,15-BISDEOXY PROSTAGLANDIN-E1 AND CONGENERS [J].

TOLMAN, EL ;

PARTRIDGE, R ;

BARRIS, ET .

PROSTAGLANDINS, 1977, 14 (01) :11-19

← 1 →