DEFECTIVE OXIDATIVE-METABOLISM OF MYODYSTROPHIC SKELETAL-MUSCLE MITOCHONDRIA

被引：26

作者：

LEE, CP

MARTENS, ME

JANKULOVSKA, L

NEYMARK, MA

机构：

[1] Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan

来源：

MUSCLE & NERVE | 1979年 / 2卷 / 05期

关键词：

D O I：

10.1002/mus.880020504

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A small‐scale procedure for preparing tightly coupled intact skeletal muscle mitochondria from myodystrophic (myd/myd) mice is described. Mitochondrial preparations derived from heart, liver, and skeletal muscle of myd/myd and their littermate (+/?) controls are characterized with respect to their cytochrome content and their oxidative and phosphorylative capacities. Our data indicate that there is an impairment in the NADH CoQ region of the respiratory chain of myodystrophic skeletal muscle mitochondria. Both heart and liver mitochondria of myd/myd exhibited normal activities of respiratory chain‐linked oxidative phosphorylation. Copyright © 1979 Houghton Mifflin Professional Publishers

引用

页码：340 / 348

页数：9

共 49 条

[1] DISORDER OF MUSCLE LIPID-METABOLISM AND MYOGLOBINURIA - ABSENCE OF CARNITINE PALMITYL TRANSFERASE [J].