COORDINATION BEHAVIOR OF METHAZOLAMIDE [N(-4-METHYL-2-SULFAMOYL-DELTA-2-1,3,4-THIADIAZOLIN-5-YLIDENE)] ACETAMIDE, AN INHIBITOR OF CARBONIC-ANHYDRASE ENZYME - SYNTHESIS, CRYSTAL-STRUCTURE AND PROPERTIES OF BIS(METHAZOLAMIDATE)TETRAMMINE NICKEL(II)

被引:19
作者
ALZUET, G
FERRER, S
BORRAS, J
SOLANS, X
FONTBARDIA, M
机构
[1] UNIV VALENCIA,FAC FARM,DEPT QUIM INORGAN,E-46010 VALENCIA,SPAIN
[2] UNIV BARCELONA,DEPT CRISTALOG MINERAL & OTROS MAT,E-08028 BARCELONA,SPAIN
关键词
D O I
10.1016/S0020-1693(00)81667-9
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The interaction of methazolamide (Hmacm) with Ni(II) ion and ammonia molecules gives rise to the complex of formula [Ni(macm)2(NH3)4]. The complex crystallizes in the monoclinic P2(1)/n space group with a = 14.255(4), b = 7.126(2), c = 12.444(3) angstrom, beta = 113.12(3)-degrees and Z = 2. The structure was refined to R = 0.065 (R(w) = 0.065). The complex consists of monomeric units which interact through hydrogen bonds and van der Waals contacts. The Ni(II) ion is coordinated with the deprotonated sulfonamido nitrogen of the macm- ligand in axial sites and the ammonia molecules in equatorial positions. IR, electronic spectra and H-1 NMR results are also reported.
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页码:257 / 261
页数:5
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