NERVE GROWTH-FACTOR INDUCES TRKA MESSENGER-RNA EXPRESSION IN CULTURED BASAL FOREBRAIN CHOLINERGIC NEURONS FROM 17-DAY FETAL RATS

被引：22

作者：

KOJIMA, M ^{[1
]}

IKEUCHI, T ^{[1
]}

HATANAKA, H ^{[1
]}

机构：

[1] OSAKA UNIV,INST PROT RES,DIV PROT BIOSYNTH,SUITA,OSAKA 565,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 169卷 / 1-2期

关键词：

HIGH-AFFINITY NGF RECEPTOR; TRKA; GENE EXPRESSION; NEURONAL DIFFERENTIATION; NEUROTROPHIC FACTOR; CHOLINE ACETYLTRANSFERASE;

D O I：

10.1016/0304-3940(94)90353-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We first examined the basal forebrain tissues for developmental changes in expression of the high-affinity NGF receptor (trkA) gene. Our reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed that trkA mRNA is present in those tissues of postnatal rats, but not in those of fetal rats. Then we determined the effect of NGF on trkA gene expression in serum-free cultures of basal forebrain neurons from 17-day fetal rats. NGF was found to induce trkA mRNA 36 h after the addition of NGF, while no trkA mRNA was detected in the absence of NGF.

引用

页码：47 / 50

页数：4

共 19 条

[1] DEVELOPMENTAL-CHANGES OF NERVE GROWTH-FACTOR AND ITS MESSENGER-RNA IN THE RAT HIPPOCAMPUS - COMPARISON WITH CHOLINE-ACETYLTRANSFERASE
AUBURGER, G
HEUMANN, R
HELLWEG, R
KORSCHING, S
THOENEN, H
[J]. DEVELOPMENTAL BIOLOGY, 1987, 120 (02) : 322 - 328
[2] TROPHIC FACTORS AND NEURONAL SURVIVAL
BARDE, YA
[J]. NEURON, 1989, 2 (06) : 1525 - 1534
[3] MEMBRANE DEPOLARIZATION INDUCES P140(TRK) AND NGF RESPONSIVENESS, BUT NOT P75(LNGFR), IN MAH CELLS
BIRREN, SJ
VERDI, JM
ANDERSON, DJ
[J]. SCIENCE, 1992, 257 (5068) : 395 - 397
[4] RAPID RADIOCHEMICAL METHOD FOR DETERMINATION OF CHOLINE-ACETYLTRANSFERASE
FONNUM, F
[J]. JOURNAL OF NEUROCHEMISTRY, 1975, 24 (02) : 407 - 409
[5] Glass David J., 1993, Trends in Cell Biology, V3, P262, DOI 10.1016/0962-8924(93)90054-5
[6] GNAHN H, 1983, DEV BRAIN RES, V9, P45, DOI 10.1016/0165-3806(83)90107-4
[7] HARTIKKA J, 1988, J NEUROSCI, V8, P2967
[8] DEVELOPMENTAL-CHANGE IN THE NERVE GROWTH-FACTOR ACTION FROM INDUCTION OF CHOLINE-ACETYLTRANSFERASE TO PROMOTION OF CELL-SURVIVAL IN CULTURED BASAL FOREBRAIN CHOLINERGIC NEURONS FROM POSTNATAL RATS
HATANAKA, H
TSUKUI, H
NIHONMATSU, I
[J]. DEVELOPMENTAL BRAIN RESEARCH, 1988, 39 (01): : 85 - 95
[9] P140TRK MESSENGER-RNA MARKS NGF-RESPONSIVE FOREBRAIN NEURONS - EVIDENCE THAT TRK GENE-EXPRESSION IS INDUCED BY NGF
HOLTZMAN, DM
LI, YW
PARADA, LF
KINSMAN, S
CHEN, CK
VALLETTA, JS
ZHOU, J
LONG, JB
MOBLEY, WC
[J]. NEURON, 1992, 9 (03) : 465 - 478
[10] INDUCTION OF TRKB BY RETINOIC ACID MEDIATES BIOLOGIC RESPONSIVENESS TO BDNF AND DIFFERENTIATION OF HUMAN NEUROBLASTOMA-CELLS
KAPLAN, DR
MATSUMOTO, K
LUCARELLI, E
THIELE, CJ
[J]. NEURON, 1993, 11 (02) : 321 - 331

← 1 2 →