ADHESIVE SIGNALING IN PLATELETS

被引：196

作者：

SHATTIL, SJ

GINSBERG, MH

BRUGGE, JS

机构：

[1] Scripps Res Inst, DEPT VASC BIOL, LA JOLLA, CA 92037 USA

[2] ARIAD PHARMACEUT INC, CAMBRIDGE, MA 02138 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 05期

关键词：

D O I：

10.1016/0955-0674(94)90096-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anucleate platelet must perform its hemostatic functions in the absence of transcriptional regulation. Central among these functions is cell adhesion, which is mediated by multiple specialized plasma membrane receptors. The adhesive function of one of the key receptors, integrin alpha(IIb)beta(3), is regulated by intracellular signals triggered by platelet agonists and antagonists. Recent evidence indicates that adhesion receptors can transduce extracellular signals into the platelet to activate intracellular signaling pathways that affect hemostasis.

引用

页码：695 / 704

页数：10

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