THE EXTRACELLULAR-MATRIX PRODUCED BY BOVINE CORNEAL ENDOTHELIAL-CELLS CONTAINS PROGELATINASE-A

被引:13
作者
MENASHI, S
VLODAVSKY, I
ISHAIMICHAELI, R
LEGRAND, Y
FRIDMAN, R
机构
[1] HADASSAH UNIV HOSP, DEPT ONCOL, IL-91120 JERUSALEM, ISRAEL
[2] WAYNE STATE UNIV, DEPT PATHOL, DETROIT, MI 48201 USA
来源
FEBS LETTERS | 1995年 / 361卷 / 01期
关键词
MATRIX METALLOPROTEINASE; EXTRACELLULAR MATRIX; GELATINASE; CORNEAL ENDOTHELIAL CELL; PROTEASE;
D O I
10.1016/0014-5793(95)00125-S
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Progelatinase A is a matrix metalloproteinase involved in the turnover of extracellular matrix (ECM). We report that the ECM produced by bovine corneal endothelial (BCE) cells contains progelatinase A free of tissue inhibitor of metalloproteinase (TIMP2). The matrix-bound progelatinase A can be activated by APMA to generate a 62 kDa and a 45 kDa species with enzymatic activity and is inhibited by TIMP2. The bound progelatinase can be released after treatment of the ECM with gelatinase B. These studies suggest that the ECM can function as a reservoir for progelatinase A which may be readily available for cells in processes such as metastasis, angiogenesis, inflammation and wound healing.
引用
收藏
页码:61 / 64
页数:4
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