PLATINUM AND PALLADIUM DERIVATIVES FOR CHEMOTHERAPY STUDIES

Analogues of cis-dichlorodiammineplatinum(II) were prepared in which substituted pyridines (A), 1-(4-aminobenzylidene) indene (B), or DL-3, 5, 3ʹ5ʹ-tetraoxo-1, 2-dipiperazinopropane (ICRF-159) was used in place of ammonia, and in some cases platinum(IV) or palladium(II) was used in place of the platinum(II). Both platinum complexes with ICRF-159 were active against leukemia 1210, but none of the others produced significant life extension following a single ip dose of 400 mg/kg. Attempts to prepare complexes of ICRF-159 with Zn(II), Mn(II), and Cr(III) were unsuccessful, but there were indications of complex formation with CuCl2and with NiCl2. © 1979, American Chemical Society. All rights reserved.