APPARENT SYNAPTIC DOPAMINE DEFICIENCY INDUCED BY WITHDRAWAL FROM CHRONIC COCAINE TREATMENT

被引：115

作者：

ROBERTSON, MW

LESLIE, CA

BENNETT, JP

机构：

[1] UNIV VIRGINIA,DEPT NEUROL,BOX 394,CHARLOTTESVILLE,VA 22908

[2] UNIV VIRGINIA,SCH MED,DEPT BEHAV MED & PSYCHIAT,CHARLOTTESVILLE,VA 22908

[3] UNIV VIRGINIA,SCH MED,DEPT PHARMACOL,CHARLOTTESVILLE,VA 22908

来源：

BRAIN RESEARCH | 1991年 / 538卷 / 02期

关键词：

COCAINE; DOPAMINE; BRAIN DIALYSIS; AUTORECEPTOR; DRUG WITHDRAWAL;

D O I：

10.1016/0006-8993(91)90451-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects on motor behavior and forebrain dopamine(DA) synaptic function of withdrawal from chronic cocaine treatment were examined with simultaneous activity monitoring and microdialysis in nucleus accumbens. Rats exhibited behavioral sensitization to daily 30 mg/kg i.p. cocaine. After 18 days of daily cocaine and 7 days of withdrawal, dialysate DA and homovanillic acid (HVA) levels were reduced 36-38%, consistent with a synaptic DA deficiency.

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页码：337 / 339

页数：3

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