BOTULINUM-A TOXIN TREATMENT FOR EYELID SPASM, SPASMODIC TORTICOLLIS AND APRAXIA OF EYELID OPENING

被引：5

作者：

DEFAZIO, G ^{[1
]}

LEPORE, V ^{[1
]}

LAMBERTI, P ^{[1
]}

LIVREA, P ^{[1
]}

FERRARI, E ^{[1
]}

机构：

[1] UNIV BARI,IST CLIN MALATTIE NERVOSE & MENTALI,I-70124 BARI,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1990年 / 11卷 / 03期

关键词：

apraxia of eyelid opening; blepharospasm; Botulinum-A toxin; hemifacial spasm; spasmodic torticollis;

D O I：

10.1007/BF02333858

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Botulinum-A toxin (botAtox) was used in the treatment of blepharospasm (BS), idiopathic hemifacial spasm (HFS), idiopathic spasmodic torticollis (ST) and apraxia of eyelid opening (AEO). The injection of 7.5-30 U botAtox per eye spread over 3 or 4 sites in the palpebral part of orbicularis palpebrae (OP) reduced palpebral spasm in 12/13 cases of BS and in 7/8 cases of HFS. The effect lasted for 14.5 weeks on average (range 4-30 weeks). Palpebral ptosis (lasting 1-3 weeks) was the most frequent side effect (16/107 eyes treated) but was not related to dose of botAtox or number of inoculation sites. Injection of 60-160 U botAtox into the sternocleidomastoid, trapezius and splenius capitis muscles reduced ST objectively in 1/4 patients for about 4 weeks. In the other patients the reduction or abolition of the hypertrophy of the previous hyperactive muscles was accompanied by persistence or rearrangement of the dystonia pattern, suggesting a change in the pattern of activity of the neck muscles after botAtox. 5 U botAtox per eye spread over 4 sites in the OP significantly reduced the frequency of the episodes of involuntary eyelid closure in 2 patients with AEO but not BS. The therapeutic effect lasted for 7 months after the first treatment and for 8 months after the second in a 46 year old woman with a 6 month history while the second patient (72 year old parkinsonian) has now completed her 3rd month of treatment. © 1990 Masson Italia Periodici.

引用

页码：275 / 280

页数：6

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