STEREO-MODULATING CATALYSIS BY EUROPIUM(III) COMPLEXES IN ALDOL REACTIONS OF CHIRAL ALPHA-ALKOXY ALDEHYDES WITH KETENE SILYL ACETALS

被引：26

作者：

TERADA, M ^{[1
]}

GU, JH ^{[1
]}

DEKA, DC ^{[1
]}

MIKAMI, K ^{[1
]}

NAKAI, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, DEPT CHEM TECHNOL, MEGURO KU, TOKYO 152, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 01期

关键词：

D O I：

10.1246/cl.1992.29

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Eu(fod)3- or Eu(dppm)3-catalyzed aldol reactions of the four chiral alpha-alkoxy aldehydes having different protecting groups with (E)- or (Z)-ketene silyl acetals are shown to provide the high levels of diastereocontrol, the sense depending on the nature of the protecting group. The catalytic stereo-modulation is explained in terms of the mode of aldehyde/catalyst complexation (chelation vs. nonchelation).

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页码：29 / 32

页数：4

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