A NOVEL HOMOISOCARBACYCLIN ANALOG WITH POTENT AND LONG-LASTING ACTIVITY

被引：4

作者：

SHIBASAKI, M ^{[1
]}

TAKAHASHI, A ^{[1
]}

AOKI, T ^{[1
]}

SATO, H ^{[1
]}

YAMADA, S ^{[1
]}

KUDO, M ^{[1
]}

KOGI, K ^{[1
]}

NARITA, S ^{[1
]}

机构：

[1] TOA EIYO LTD, FUKUSHIMA RES LABS, IIZUKA, FUKUSHIMA 96002, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 01期

关键词：

ISOCARBACYCLIN ANALOG; HOMOISOCARBACYCLIN ANALOG; TY-11223; PROSTACYCLIN; ILOPROST; PLATELET ANTIAGGREGATION ACTIVITY; HYPOTENSIVE EFFECT;

D O I：

10.1248/cpb.40.279

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A synthesis of a novel and chemically stable homoisocarbacyclin analogy, TY-11223 (3), has been accomplished. The analog (3), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.

引用

页码：279 / 281

页数：3

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