THE MEMBRANE HYPOTHESIS OF SCHIZOPHRENIA

被引：286

作者：

HORROBIN, DF

GLEN, AIM

VADDADI, K

机构：

[1] CRAIG DUNAIN HOSP,HIGHLAND PSYCHIAT RES GRP,INVERNESS,SCOTLAND

[2] MAROONDAH HOSP,MELBOURNE,VIC,AUSTRALIA

来源：

SCHIZOPHRENIA RESEARCH | 1994年 / 13卷 / 03期

关键词：

PHOSPHOLIPID METABOLISM; CELL MEMBRANE; HYPOTHESIS; (SCHIZOPHRENIA);

D O I：

10.1016/0920-9964(94)90043-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The phospholipid structure of neuronal membranes is essential for, normal functioning of the nervous system. Evidence is accumulating that phospholipid metabolism in both brain and red blood cells may be disturbed in schizophrenia. In particular, in patients with negative symptoms, levels of arachidonic acid and docosahexanoic acid in red blood cell membrane phospholipids are severely abnormal. The membrane hypothesis of schizophrenia may represent a new and fruitful paradigm for future research.

引用

页码：195 / 207

页数：13

共 79 条

[1] EFFECT OF ADP ON PGE1 FORMATION IN BLOOD-PLATELETS FROM PATIENTS WITH DEPRESSION, MANIA AND SCHIZOPHRENIA
ABDULLA, YH
HAMADAH, K
[J]. BRITISH JOURNAL OF PSYCHIATRY, 1975, 127 (DEC) : 591 - 595
[2] FATTY-ACIDS IN PLASMA PHOSPHOLIPIDS AND CHOLESTEROL ESTERS FROM IDENTICAL-TWINS CONCORDANT AND DISCORDANT FOR SCHIZOPHRENIA
BATES, C
HORROBIN, DF
ELLS, K
[J]. SCHIZOPHRENIA RESEARCH, 1991, 6 (01) : 1 - 7
[3] SPECIFIC RECEPTOR-MEDIATED INHIBITION OF CYCLIC-AMP SYNTHESIS BY DOPAMINE IN A NEURO-BLASTOMA X BRAIN HYBRID CELL-LINE NCB-20
BERRYKRAVIS, E
FREEDMAN, SB
DAWSON, G
[J]. JOURNAL OF NEUROCHEMISTRY, 1984, 43 (02) : 413 - 420
[4] BRENNER RR, 1982, PROGR LIPID RES, V20, P41
[5] BRUS R, 1983, BIOMED BIOCHIM ACTA, V42, P1211
[6] LONG-TERM FEEDING OF FORMULAS HIGH IN LINOLENIC ACID AND MARINE OIL TO VERY-LOW-BIRTH-WEIGHT INFANTS - PHOSPHOLIPID FATTY-ACIDS
CARLSON, SE
COOKE, RJ
RHODES, PG
PEEPLES, JM
WERKMAN, SH
TOLLEY, EA
[J]. PEDIATRIC RESEARCH, 1991, 30 (05) : 404 - 412
[7] FAT CONSUMPTION AND SCHIZOPHRENIA
CHRISTENSEN, O
CHRISTENSEN, E
[J]. ACTA PSYCHIATRICA SCANDINAVICA, 1988, 78 (05) : 587 - 591
[8] A NOVEL ARACHIDONIC ACID-SELECTIVE CYTOSOLIC PLA2 CONTAINS A CA2+-DEPENDENT TRANSLOCATION DOMAIN WITH HOMOLOGY TO PKC AND GAP
CLARK, JD
LIN, LL
KRIZ, RW
RAMESHA, CS
SULTZMAN, LA
LIN, AY
MILONA, N
KNOPF, JL
[J]. CELL, 1991, 65 (06) : 1043 - 1051
[9] PURIFICATION OF A 110-KILODALTON CYTOSOLIC PHOSPHOLIPASE-A2 FROM THE HUMAN MONOCYTIC CELL-LINE U937
CLARK, JD
MILONA, N
KNOPF, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) : 7708 - 7712
[10] CONNOR WE, 1993, FASEB J, V7, pA152

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