ANTI-CD4 MEDIATES CLONAL ANERGY DURING TRANSPLANTATION TOLERANCE INDUCTION

被引：121

作者：

ALTERS, SE ^{[1
]}

SHIZURU, JA ^{[1
]}

ACKERMAN, J ^{[1
]}

GROSSMAN, D ^{[1
]}

SEYDEL, KB ^{[1
]}

FATHMAN, CG ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,DIV IMMUNOL,S-021,STANFORD,CA 94305

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 173卷 / 02期

关键词：

D O I：

10.1084/jem.173.2.491

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Depletion of CD4 cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IE(k) donor to a diabetic C57Bl/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V-beta-11 T cells. Instead, a state of clonal anergy is induced in both the CD4 V-beta-11 and CD8 V-beta-11 T cell subsets. This clonal anergy can be partially overcome in vitro by the addition of recombinant interleukin 2.

引用

页码：491 / 494

页数：4

共 18 条

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