5-AMINOSALICYLIC ACID IS A POTENT INHIBITOR OF INTERLEUKIN 1-BETA PRODUCTION IN ORGAN-CULTURE OF COLONIC BIOPSY SPECIMENS FROM PATIENTS WITH INFLAMMATORY BOWEL-DISEASE

被引：121

作者：

MAHIDA, YR

LAMMING, CED

GALLAGHER, A

HAWTHORNE, AB

HAWKEY, CJ

机构：

[1] Department of Therapeutics, Queen's Medical Centre

[2] Department of Therapeutics, University Hospital, Queen's Medical Centre

来源：

GUT | 1991年 / 32卷 / 01期

关键词：

D O I：

10.1136/gut.32.1.50

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Interleukin 1-beta in biopsy specimens from inflamed colonic mucosa of patients with active inflammatory bowel disease was studied. Compared with normal colonic mucosal biopsy specimens, a significantly greater amount of interleukin 1-beta was present in rectal mucosa before (median (range) 4.3 (2.0-11.8) upsilon-119.2 (30.1-286.8) pg/mg; p < 0.01) and produced during organ culture (39.1 (9.4-106.8) upsilon-97.6 (08.2-991.6) pg/mg; p < 0.01). Values of interleukin 1-beta after culture correlated with concentrations of thromboxane B2. Organ culture of inflamed biopsy specimens in the presence of 5 aminosalicylic acid and dexamethasone reduced the amount of interleukin 1-beta detected. At the doses studied, 5 aminosalicylic acid also reduced the amount of leukotriene B4 detected after culture.

引用

页码：50 / 54

页数：5

共 27 条

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