TRANSFORMING GROWTH-FACTORS TYPE-BETA-1 AND TYPE-BETA-2 SUPPRESS RAT ASTROCYTE AUTOANTIGEN PRESENTATION AND ANTAGONIZE HYPERINDUCTION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION BY INTERFERON-GAMMA AND TUMOR NECROSIS FACTOR-ALPHA

被引：90

作者：

SCHLUESENER, HJ

机构：

[1] Clinical Research Unit for Multiple Sclerosis, Max-Planck-Society

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 27卷 / 01期

关键词：

Ia; Interleukin; Major histocompatibility complex antigen; Transforming growth factor-β;

D O I：

10.1016/0165-5728(90)90134-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transforming growth factors (TGF) type β1 and β2 are regulatory cytokines strongly affecting rat astrocyte immune functions. Both cytokines suppressed presentation of autoantigen by astrocytes: highly encephalotogenic T cells cocultured with TGF-β-treated astrocytes in the presence of myelin basic protein did not become activated to transfer experimental allergic encephalomyelitis, a central nervous system (CNS) autoimmune disease. Furthermore, TGF-β1 and -β2 antagonized hyperinduction of astrocyte major histocompatibility complex (MHC) class II antigen expression by interferon-γ and tumor necrosis factor-α. Thus, TGF-β might be a potential regulator of CNS inflammation. © 1990.

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页码：41 / 47

页数：7

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