BETA-AMYLOID NEUROTOXICITY - A DISCUSSION OF INVITRO FINDINGS

被引：113

作者：

COTMAN, CW

PIKE, CJ

COPANI, A

机构：

[1] Irvine Research Unit in Brain Aging, University of California, Irvine

来源：

NEUROBIOLOGY OF AGING | 1992年 / 13卷 / 05期

关键词：

ALZHEIMERS DISEASE; BETA-AMYLOID; NEUROTOXICITY; AGGREGATION;

D O I：

10.1016/0197-4580(92)90060-B

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Significant advances in Alzheimer's disease (AD) research require definitive, reproducible findings from all employed paradigms. Recently, the existing in vitro data addressing the possible contribution of beta-amyloid protein to AD neuropathology have been the subject of controversey. We summarize and interpret existing data and discuss relevant methodological issues. We suggest that in vitro data support the conclusion that beta-amyloid peptides decrease the viability of cultured neurons and that this effect can be enhanced by subsequent insults.

引用

页码：587 / 590

页数：4

共 21 条

[1] SOLUTION STRUCTURES OF BETA PEPTIDE AND ITS CONSTITUENT FRAGMENTS - RELATION TO AMYLOID DEPOSITION [J].