STABLE ISOSTERES OF NEUROTENSIN C-TERMINAL PENTAPEPTIDES DERIVED BY MODIFICATION OF THE AMIDE FUNCTION

被引：23

作者：

CHRISTOS, TE

ARVANITIS, A

CAIN, GA

JOHNSON, AL

POTTORF, RS

TAM, SW

SCHMIDT, WK

机构：

[1] The Dupont Merck Pharmaceutical Company, Wilmington, DE 19880-0353

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80282-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of amide bond modified neurotensin c-terminal pentapeptides has been prepared and tested for their in vivo analgesic properties. Reduced amide function and trans double bond isosteres did show analgesic activity.

引用

页码：1035 / 1040

页数：6

共 19 条

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