THE COMPARATIVE INVITRO PHARMACOLOGY OF LEUKOTRIENE-D4 AND ITS ISOMERS

被引：24

作者：

BAKER, SR

BOOT, JR

JAMIESON, WB

OSBORNE, DJ

SWEATMAN, WJF

机构：

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1981年 / 103卷 / 04期

关键词：

D O I：

10.1016/0006-291X(81)90258-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 5R,6S and 5S,6R isomers of a component of slow reacting substance of anaphylaxis, leukotriene D4 (LTD4), 9-cis-LTD4, 9-cis, 11-trans-LTD4 and 11-trans-LTD4 were synthesized for comparative pharmacological studies on guinea pig intestinal and respiratory smooth muscle preparations. The 5S,6R isomers are biologically active, modification of the double bond stereochemistry causing only a moderate reduction in activity. The 5R,6S isomers possess approximately 1% the biological activity of their respective 5S,6R forms.

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页码：1258 / 1264

页数：7

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