IMPROVEMENT IN CIRCULATORY AND OXYGENATION STATUS BY PERFLUBRON EMULSION (OXYGENT(TM) HT) IN A CANINE MODEL OF SURGICAL HEMODILUTION

被引：4

作者：

CERNAIANU, AC ^{[1
]}

SPENCE, RK ^{[1
]}

VASSILIDZE, TV ^{[1
]}

GALLUCCI, JG ^{[1
]}

GAPRINDASHVILI, T ^{[1
]}

OLAH, A ^{[1
]}

WEISS, RL ^{[1
]}

CILLEY, JH ^{[1
]}

KEIPERT, PE ^{[1
]}

FAITHFULL, NS ^{[1
]}

DELROSSI, AJ ^{[1
]}

机构：

[1] ALLIANCE PHARMACEUT CORP, SAN DIEGO, CA USA

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 1994年 / 22卷 / 04期

关键词：

D O I：

10.3109/10731199409138795

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To examine the effect of a low dose of Oxygent(TM) HT on hemodynamics and oxygen transport variables in a canine model of profound surgical hemodilution, two groups of adult anesthetized splenectomized beagles were hemodiluted with Ringer's solution to Hb 7 g/dL. The treated group received 1 mL/kg Oxygent(TM) HT (90% w/v perflubron emulsion [perfluorooctyl bromide], Alliance Pharmaceutical Corp.) and both groups (7 controls and 10 treated) were further hemodiluted using 6% hydroxyethyl starch until cardiorespiratory decompensation occurred. Pulmonary artery catheterization data and oxygen transport variables were recorded at Hb decrements of 1 g/dL breathing room air. There was no difference among groups during initial hemodilution. However, in the Oxygent(TM) HT group there was a statistically significant improvement in mean arterial pressure, CVP, cardiac output, PvO(2), SvO(2), DO2 and pulmonary venous admixture Shunt during profound hemodilution to Hb levels of 6, 5, and 4 g/dL. A low dose of Oxygent(TM) HT offered benefit in improving hemodynamics and oxygen transport parameters even under air breathing conditions in a model of surgical hemodilution. This effect was most apparent at lower levels of Hb.

引用

页码：965 / 977

页数：13

共 39 条

[1] THE MINIMUM ACCEPTABLE LEVEL OF HEMOGLOBIN [J].