HIGH ACETYLCHOLINE CONCENTRATIONS CAUSE RAPID INACTIVATION BEFORE FAST DESENSITIZATION IN NICOTINIC ACETYLCHOLINE-RECEPTORS FROM TORPEDO

被引:37
作者
FORMAN, SA
MILLER, KW
机构
[1] MASSACHUSETTS GEN HOSP,DEPT ANESTHESIA,BOSTON,MA 02114
[2] HARVARD UNIV,COMM HIGHER DEGREES BIOPHYS,CAMBRIDGE,MA 02139
[3] MIT,PROGRAM HLTH SCI & TECHNOL,CAMBRIDGE,MA 02142
[4] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115
关键词
D O I
10.1016/S0006-3495(88)82939-4
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:149 / 158
页数:10
相关论文
共 46 条
[11]   ACETYLCHOLINE-RECEPTOR - AN ALLOSTERIC PROTEIN [J].
CHANGEUX, JP ;
DEVILLERSTHIERY, A ;
CHEMOUILLI, P .
SCIENCE, 1984, 225 (4668) :1335-1345
[12]   2-COMPONENT DESENSITIZATION AT THE NEUROMUSCULAR-JUNCTION OF THE FROG [J].
CHESNUT, TJ .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 336 (MAR) :229-241
[13]   AFFINITY LABELING OF ONE OF 2 ALPHA-NEUROTOXIN BINDING-SITES IN ACETYLCHOLINE-RECEPTOR FROM TORPEDO-CALIFORNICA [J].
DAMLE, VN ;
KARLIN, A .
BIOCHEMISTRY, 1978, 17 (11) :2039-2045
[14]   ACTIVATION AND DESENSITIZATION OF TORPEDO ACETYLCHOLINE-RECEPTOR - EVIDENCE FOR SEPARATE BINDING-SITES [J].
DUNN, SMJ ;
RAFTERY, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (22) :6757-6761
[15]   DESENSITIZATION AT THE FROG NEUROMUSCULAR-JUNCTION - A BIPHASIC PROCESS [J].
FELTZ, A ;
TRAUTMANN, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1982, 322 (JAN) :257-272
[16]   IS AGONIST SELF-INHIBITION AT THE NICOTINIC ACETYLCHOLINE-RECEPTOR A NONSPECIFIC ACTION [J].
FORMAN, SA ;
FIRESTONE, LL ;
MILLER, KW .
BIOCHEMISTRY, 1987, 26 (10) :2807-2814
[17]   COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS [J].
FURCHGOTT, RF ;
BURSZTYN, P .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1967, 144 (A2) :882-+
[18]   SITES OF ACTION OF PROCAINE AT THE MOTOR ENDPLATE [J].
GAGE, PW ;
HAMILL, OP ;
WACHTEL, RE .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 335 (FEB) :123-137
[19]   THE CHANNEL-BLOCKING ACTION OF METHONIUM COMPOUNDS ON RAT SUBMANDIBULAR GANGLION-CELLS [J].
GURNEY, AM ;
RANG, HP .
BRITISH JOURNAL OF PHARMACOLOGY, 1984, 82 (03) :623-642
[20]   RAPID KINETICS OF AGONIST BINDING AND PERMEABILITY RESPONSE ANALYZED IN PARALLEL ON ACETYLCHOLINE-RECEPTOR RICH MEMBRANES FROM TORPEDO-MARMORATA [J].
HEIDMANN, T ;
BERNHARDT, J ;
NEUMANN, E ;
CHANGEUX, JP .
BIOCHEMISTRY, 1983, 22 (23) :5452-5459