CHANGES RESEMBLING LUPUS ERYTHEMATOSUS AFTER PROLONGED TREATMENT WITH RO-4-4602, A POTENT INHIBITOR OF 5-HTP-CARBOXYLIASE, IN WHITE RATS

被引：5

作者：

CHRUSCIEL, M

机构：

[1] Department of Pharmacology, Silesian Academy of Medicine

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 8卷 / 02期

关键词：

5-HTP-carboxyliase; Carboxyliase inhibition; Pseudo LE-cells Lupus erythematosus; Rats; Ro-4-4602;

D O I：

10.1016/0014-2999(69)90076-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A potent inhibitor of 5-HTP-carboxyliase, Ro-4-4602, was given to rats in various doses for 9-64 weeks. Changes similar to the hydralazine syndrome (pseudo-LE cells increase of sedimentation rate, leucopenia in one group of rats, and collagenosis-like morphological changes) were provoked. The role of inhibition of carboxyliase in the hydralazine syndrome is postulated. © 1969.

引用

页码：192 / +

页数：1

共 23 条

[1] THE DECARBOXYLATION OF AMINO ACIDS RELATED TO TYROSINE AND THEIR AWAKENING ACTION IN RESERPINE-TREATED MICE [J].