GLUTAMATE RECEPTOR-CHANNEL GATING - MAXIMUM-LIKELIHOOD ANALYSIS OF GIGAOHM SEAL RECORDINGS FROM LOCUST MUSCLE

被引:21
作者
BATES, SE [1 ]
SANSOM, MSP [1 ]
BALL, FG [1 ]
RAMSEY, RL [1 ]
USHERWOOD, PNR [1 ]
机构
[1] UNIV NOTTINGHAM, DEPT MATH, NOTTINGHAM NG7 2RD, ENGLAND
关键词
D O I
10.1016/S0006-3495(90)82367-5
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Gigaohm recordings have been made from glutamate receptor channels in excised, outside-out patches of collagenase-treated locust muscle membrane. The channels in the excised patches exhibit the kinetic state switching first seen in megaohm recordings from intact muscle fibers. Analysis of channel dwell time distributions reveals that the gating mechanism contains at least four open states and at least four closed states. Dwell time autocorrelation function analysis shows that there are at least three gateways linking the open states of the channel with the closed states. A maximum likelihood procedure has been used to fit six different gating models to the single channel data. Of these models, a cooperative model yields the best fit, and accurately predicts most features of the observed channel gating kinetics. © 1990, The Biophysical Society. All rights reserved.
引用
收藏
页码:219 / 229
页数:11
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