STUDIES ON QUINAZOLINONES .3. NOVEL AND EFFICIENT ROUTE TO THE SYNTHESIS OF CONFORMATIONALLY RESTRICTED ANALOGS OF KETANSERIN AND SGB-1534 AS ANTIHYPERTENSIVE AGENTS

被引：20

作者：

CHERN, JW ^{[1
]}

SHIAU, CY ^{[1
]}

LU, GY ^{[1
]}

机构：

[1] NATL DEF MED CTR,MED LABS,TAIPEI,TAIWAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)81152-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bromocyclization of N-allyl quinazoline derivatives with N-bromosuccinimide results in the formation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives. Substitution reactions of the resulting angularly tricycles led to discover a novel potent antihypertensive agent.

引用

页码：571 / &

共 11 条

[1]

[Anonymous], COMMUNICATION

[2]

Bartlett P. A., 1984, ASYMMETRIC SYNTHESIS, V3, P411

[3] A NEW BETA-LACTAM SYNTHESIS [J].