STUDIES ON QUINAZOLINONES .3. NOVEL AND EFFICIENT ROUTE TO THE SYNTHESIS OF CONFORMATIONALLY RESTRICTED ANALOGS OF KETANSERIN AND SGB-1534 AS ANTIHYPERTENSIVE AGENTS

被引:20
作者
CHERN, JW [1 ]
SHIAU, CY [1 ]
LU, GY [1 ]
机构
[1] NATL DEF MED CTR,MED LABS,TAIPEI,TAIWAN
关键词
D O I
10.1016/S0960-894X(01)81152-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Bromocyclization of N-allyl quinazoline derivatives with N-bromosuccinimide results in the formation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives. Substitution reactions of the resulting angularly tricycles led to discover a novel potent antihypertensive agent.
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页码:571 / &
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