SLEEP EEG AND NOCTURNAL SECRETION OF TESTOSTERONE AND CORTISOL IN PATIENTS WITH MAJOR ENDOGENOUS-DEPRESSION DURING ACUTE PHASE AND AFTER REMISSION

被引：45

作者：

STEIGER, A ^{[1
]}

VONBARDELEBEN, U ^{[1
]}

WIEDEMANN, K ^{[1
]}

HOLSBOER, F ^{[1
]}

机构：

[1] UNIV MAINZ, DEPT PSYCHIAT, W-6500 MAINZ, GERMANY

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1991年 / 25卷 / 04期

关键词：

D O I：

10.1016/0022-3956(91)90021-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Sleep EEG and the nocturnal secretion of cortisol and testosterone in 12 male patients (mean age 46.4 +/- 11.26 years) with major endogenous depression were investigated concomitantly during acute depression, before treatment and after recovery and drug cessation. Testosterone concentration increased after remission, while cortisol secretion decreased. Sleep EEG disturbances remained unchanged in remitted patients. The data suggest that a blunted testosterone and an elevated cortisol secretion are state markers of acute depression, which normalize independently from sleep structure. An interaction between the hypothalamic-pituitary-gonadal axis and the limbic-hypothalamic-pituitary-adrenocortical axis appears likely.

引用

页码：169 / 177

页数：9

共 33 条

[1] EVIDENCE FOR THE INVOLVEMENT OF ENDOGENOUS OPIOIDS IN THE INHIBITION OF LUTEINIZING-HORMONE BY CORTICOTROPIN-RELEASING FACTOR [J].