SEQUENCES OF 4 PREVIOUSLY UNDESCRIBED HUMAN T-CELL RECEPTOR BETA-CHAIN VARIABLE GENES

被引：10

作者：

HANSEN, T

QVIGSTAD, E

LUNDIN, KEA

THORSBY, E

机构：

[1] Institute of Transplantation Immunology, National Hospital, Oslo

来源：

TISSUE ANTIGENS | 1991年 / 38卷 / 03期

关键词：

GENE AMPLIFICATION; LYMPHOCYTES-T; RECEPTORS; IMMUNOLOGICAL ANALYSIS; IMMUNOLOGICAL GENTETICS;

D O I：

10.1111/j.1399-0039.1991.tb02020.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

T-cell receptor beta chain mRNA from 4 human T-lymphocyte clones was reverse transcribed, amplified by PCR, cloned in M13 and sequenced. Four hitherto undescribed variable genes were found. One of them (V-beta-IW22) showe the highest homology (74.5%) to V-beta-1. Two others (V-beta-IW6 and V-beta-IW10) belonged to the recently described V-beta-21 family. The last gene (V-beta-VW114) belonged to the V-beta-9 family. However, the latter gene a is pseudogene because of an in-frame stop codon.

引用

收藏

页码：99 / 103

页数：5

相关论文

共 10 条

[1] T-CELL ANTIGEN RECEPTOR GENES AND T-CELL RECOGNITION [J].

DAVIS, MM ;

BJORKMAN, PJ .

NATURE, 1988, 334 (6181) :395-402

[2] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[3] SEQUENCES AND DIVERSITY OF HUMAN T-CELL RECEPTOR BETA-CHAIN VARIABLE REGION GENES [J].

KIMURA, N ;

TOYONAGA, B ;

YOSHIKAI, Y ;

TRIEBEL, F ;

DEBRE, P ;

MINDEN, MD ;

MAK, TW .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (03) :739-750

[4]

LUNDIN KEA, 1990, J IMMUNOL, V145, P136

[5] ALLELIC SEQUENCE VARIATIONS IN THE HYPERVARIABLE REGION OF A T-CELL RECEPTOR BETA-CHAIN - CORRELATION WITH RESTRICTION FRAGMENT LENGTH POLYMORPHISM IN HUMAN FAMILIES AND POPULATIONS [J].

ROBINSON, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9422-9426

[6]

Sambrook J., 1989, MOL CLONING

[7] STRUCTURE AND DIVERSITY OF THE HUMAN T-CELL RECEPTOR BETA-CHAIN VARIABLE REGION GENES [J].

TILLINGHAST, JP ;

BEHLKE, MA ;

LOH, DY .

SCIENCE, 1986, 233 (4766) :879-883

[8] SEQUENCE AND EVOLUTION OF THE HUMAN T-CELL ANTIGEN RECEPTOR BETA-CHAIN GENES [J].

TUNNACLIFFE, A ;

KEFFORD, R ;

MILSTEIN, C ;

FORSTER, A ;

RABBITTS, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) :5068-5072

[9]

WILSON RK, 1990, IMMUNOGENETICS, V32, P406

[10] STRUCTURE, ORGANIZATION AND POLYMORPHISM OF MURINE AND HUMAN T-CELL RECEPTOR ALPHA-CHAIN AND BETA-CHAIN GENE FAMILIES [J].

WILSON, RK ;

LAI, E ;

CONCANNON, P ;

BARTH, RK ;

HOOD, LE .

IMMUNOLOGICAL REVIEWS, 1988, 101 :149-172