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NEW CHOLESTANE BISDESMOSIDES FROM THE BULBS OF ORNITHOGALUM-THYRSOIDES

被引：22
作者：
KUBO, S
MIMAKI, Y
SASHIDA, Y
NIKAIDO, T
OHMOTO, T
机构：
[1] TOKYO COLL PHARM, 1432-1 HORINOUCHI, HACHIOJI, TOKYO 19203, JAPAN
[2] TOHO UNIV, FAC PHARMACEUT SCI, FUNABASHI, CHIBA 274, JAPAN
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1992年 / 65卷 / 04期
关键词：
D O I：
10.1246/bcsj.65.1120
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four new cholestane bisdesmosides have been isolated from the fresh bulbs of Ornithogalum thyrsoides. Their structures were determined by spectroscopic analysis and chemical evidence to be (22S)-5-alpha-cholestane-1-beta,3-beta,16-beta,22-tetrol 1-O-alpha-L-rhamnopyranoside 16-O-beta-D-glucopyranoside (1), (22S)-5-alpha-cholestane-1-beta,3-beta,16-beta,22-tetrol 1-O-alpha-L-rhamnopyranoside 16-O-(6-O-acetyl-beta-D-glucopyranoside) (2), (22S)-5-alpha-cholest-24-ene-1-beta,3-beta, 16-beta,22-tetrol 1-O-alpha-L-rhamnopyranoside 16-O-beta-D-glucopyranoside (3), and (22S)-5-alpha-cholest-24-ene-1-beta,3-beta,16-beta,22-tetrol 1-O-alpha-L-rhamnopyranoside 16-O-(6-O-acetyl-beta-D-glucopyranoside) (4), respectively. An advanced Mosher's method was applied to determine the C-22 absolute configuration. Compound 4 showed inhibitory activity on cyclic AMP phosphodiesterase.
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收藏
页码：1120 / 1124
页数：5
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