A METASTATIC MODEL OF HUMAN COLON CANCER CONSTRUCTED USING CECAL IMPLANTATION OF CANCER-TISSUE IN NUDE-MICE

被引：20

作者：

FURUKAWA, T ^{[1
]}

KUBOTA, T ^{[1
]}

WATANABE, M ^{[1
]}

KUO, TH ^{[1
]}

NISHIBORI, H ^{[1
]}

KASE, S ^{[1
]}

SAIKAWA, Y ^{[1
]}

TANINO, H ^{[1
]}

TERAMOTO, T ^{[1
]}

ISHIBIKI, K ^{[1
]}

KITAJIMA, M ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT SURG,35 SHINANOMACHI,SHINJUKU KU,TOKYO 160,JAPAN

来源：

SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY | 1993年 / 23卷 / 05期

关键词：

HUMAN COLON CANCER; METASTASES; NUDE MOUSE;

D O I：

10.1007/BF00309500

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.

引用

页码：420 / 423

页数：4

共 19 条

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