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IDENTIFICATION OF DISTINCT P-GLYCOPROTEIN GENE-SEQUENCES IN RAT

被引：44
作者：
DEUCHARS, KL
DUTHIE, M
LING, V
机构：
[1] PRINCESS MARGARET HOSP,ONTARIO CANC INST,500 SHERBOURNE ST,TORONTO M4X 1K9,ONTARIO,CANADA
[2] UNIV TORONTO,DEPT MED BIOPHYS,TORONTO M5S 1A1,ONTARIO,CANADA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1130卷 / 02期
基金：
美国国家卫生研究院;
关键词：
MULTIDRUG RESISTANCE; MULTIGENE FAMILY; 3' UNTRANSLATED REGION; PEXI/172; P-GLYCOPROTEIN-LIKE GENE SEQUENCE;
D O I：
10.1016/0167-4781(92)90523-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In higher vertebrates, P-glycoprotein is usually encoded by a small family of genes. We have determined that the rat contains three P-glycoprotein genes and have cloned distinct genomic fragments containing the putative 3' untranslated regions of these P-glycoprotein genes. Sequence analysis indicates that the rat P-glycoprotein genes belong to the three P-glycoprotein classes identified in mammals. These cloned sequences will be useful for delineating the expression of P-glycoprotein genes in the rat. We have also isolated a fourth clone which contains only a short, but highly conserved P-glycoprotein domain. This clone appears not be a member of the P-glycoprotein gene family, and its relationship to P-glycoprotein is unknown.
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页码：157 / 165
页数：9
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