POLYSACCHARIDES IN FUNGI .31. STRUCTURAL FEATURES AND HYPOGLYCEMIC ACTIVITIES OF 2 POLYSACCHARIDES FROM A HOT-WATER EXTRACT OF AGROCYBE-CYLINDRACEA

被引:62
作者
KIHO, T [1 ]
SOBUE, S [1 ]
UKAI, S [1 ]
机构
[1] GIFU PHARMACEUT UNIV,GIFU 502,JAPAN
关键词
D O I
10.1016/0008-6215(94)84277-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A glucan (AG-HN1, [alpha](D) +24 degrees) and a heteroglycan (AG-HN2, [alpha](D) + 26 degrees) were isolated from a hot-water extract of the fruiting bodies of Agrocybe cylindracea. The structures were investigated by a combination of chemical and spectroscopic methods. The results indicated that high molecular weight glucan AG-HN1 is primarily a beta-(1 --> 6)-branched (1 --> 3)-beta-D-glucan containing small amounts of (1 --> 4)-linked and (1 --> 6)-linked glucopyranosyl residues. Low molecular weight heteroglycan AG-HN2 gives galactose, glucose, fucose, and mannose on hydrolysis and appears to be chiefly composed of (1 --> 6)-linked gluco- and galacto-pyranosyl residues, many of them branched, and various nonreducing terminal residues. AG-HN1 showed a remarkable hypoglycemic activity in both normal and streptozotocin-induced diabetic mice by ip administration, and its activity was higher than that of AG-HN2.
引用
收藏
页码:81 / 87
页数:7
相关论文
共 11 条
[1]   GAS-LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY IN METHYLATION ANALYSIS OF POLYSACCHARIDES [J].
BJORNDAL, H ;
HELLERQV.CG ;
LINDBERG, B ;
SVENSSON, S .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1970, 9 (08) :610-&
[2]   C-13 NUCLEAR MAGNETIC-RESONANCE DATA FOR OLIGOSACCHARIDES [J].
BOCK, K ;
PEDERSEN, C ;
PEDERSEN, H .
ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1984, 42 :193-225
[3]   COLORIMETRIC METHOD FOR DETERMINATION OF SUGARS AND RELATED SUBSTANCES [J].
DUBOIS, M ;
GILLES, KA ;
HAMILTON, JK ;
REBERS, PA ;
SMITH, F .
ANALYTICAL CHEMISTRY, 1956, 28 (03) :350-356
[4]  
HAKOMORI SI, 1964, J BIOCHEM-TOKYO, V55, P205
[5]   POLYSACCHARIDES IN FUNGI .13. (1-]3)-ALPHA-D-GLUCAN FROM AN ALKALINE EXTRACT OF AGROCYBE-CYLINDRACEA, AND ANTITUMOR-ACTIVITY OF ITS O-(CARBOXYMETHYL)ATED DERIVATIVES [J].
KIHO, T ;
YOSHIDA, I ;
NAGAI, K ;
UKAI, S ;
HARA, C .
CARBOHYDRATE RESEARCH, 1989, 189 :273-279
[6]   HYPOGLYCEMIC ACTIVITY OF POLYSACCHARIDE FRACTION FROM RHIZOME OF REHMANNIA-GLUTINOSA LIBOSCH F-HUEICHINGENSIS HSIAO AND THE EFFECT ON CARBOHYDRATE-METABOLISM IN NORMAL MOUSE-LIVER [J].
KIHO, T ;
WATANABE, T ;
NAGAI, K ;
UKAI, S .
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1992, 112 (06) :393-400
[7]  
KIHO T, 1992, CHEM PHARM BULL, V40, P2110, DOI 10.1248/cpb.40.2110
[8]  
KIHO T, 1987, CHEM PHARM BULL, V35, P4286
[9]  
KIHO T, 1992, CHEM PHARM BULL, V40, P2212, DOI 10.1248/cpb.40.2212
[10]   ANTIDIABETES .36. ANTICOMPLEMENTARY AND HYPOGLYCEMIC ACTIVITY OF OKRA AND HIBISCUS MUCILAGES [J].
TOMODA, M ;
SHIMIZU, N ;
GONDA, R ;
KANARI, M ;
YAMADA, H ;
HIKINO, H .
CARBOHYDRATE RESEARCH, 1989, 190 (02) :323-328