INCREASED TRANSCRIPTION OF INTERLEUKIN-6 IN THE BRAINS OF MICE WITH CHRONIC ENTEROVIRUS INFECTION

被引：11

作者：

GILLESPIE, JS

CAVANAGH, HMA

BEHAN, WMH

MORRISON, LJA

MCGARRY, F

BEHAN, PO

机构：

[1] UNIV GLASGOW,SO GEN HOSP,DEPT NEUROL,GLASGOW G51 4TF,SCOTLAND

[2] UNIV GLASGOW,WESTERN INFIRM,DEPT PATHOL,GLASGOW G11 6NT,SCOTLAND

来源：

JOURNAL OF GENERAL VIROLOGY | 1993年 / 74卷

关键词：

D O I：

10.1099/0022-1317-74-4-741

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An animal model of chronic enteroviral infection was established by using PCR to detect viral genomes in animal tissues and to compare levels of transcription of a variety of cytokines in the brain. Chronic cocksackie-virus B1 infection was found in both brain and skeletal muscle of mice infected as neonates. The viral infection cleared by 240 days post-infection. Elevated levels of tumour necrosis factor alpha and interleukin-6 (IL-6) would appear to be linked to acute and chronic infection respectively. Levels of IL-6 return to normal upon clearance of the virus.

引用

页码：741 / 743

页数：3

共 16 条

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