SYNTHESIS AND CARDIOTONIC ACTIVITY OF ARYL-SUBSTITUTED OR PYRIDYL-SUBSTITUTED FUSED IMIDAZOLES

被引：22

作者：

ANDREANI, A ^{[1
]}

RAMBALDI, M ^{[1
]}

LOCATELLI, A ^{[1
]}

BOSSA, R ^{[1
]}

SALVATORE, G ^{[1
]}

GALATULAS, I ^{[1
]}

机构：

[1] UNIV MILAN, DEPT PHARMACOL, CTM, I-20129 MILAN, ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 29卷 / 05期

关键词：

FUSED IMIDAZOLES; PYRIDYL GROUP; 2,5-DIMETHOXYPHENYL GROUP; CARDIOTONIC ACTIVITY;

D O I：

10.1016/0223-5234(94)90057-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of 4 different fused imidazoles bearing a 2,5-dimethoxyphenyl group or a pyridyl group are reported. All the heterocycles, except 2a, display positive inotropic activity. Some are approximately equipotent with sulmazole, and the imidazo[2,1-b]benzothiazole that bears a 4-pyridyl group is the most active of whole series.

引用

页码：339 / 342

页数：4

共 10 条

[1]

ANDREANI A, 1986, EUR J MED CHEM, V21, P55

[2]

ANDREANI A, 1986, EUR J MED CHEM, V21, P451

[3]

ANDREANI A, 1985, EUR J MED CHEM, V20, P93

[4] SYNTHESIS AND CARDIOTONIC ACTIVITY OF 2,5-DIMETHOXYPHENYLIMIDAZO[2,1-B]THIAZOLES [J].

ANDREANI, A ;

RAMBALDI, M ;

LOCATELLI, A ;

BOSSA, R ;

GALATULAS, I ;

NINCI, M .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (04) :431-433

[5]

ANDREANI A, 1984, EUR J MED CHEM, V19, P219

[6] CARDIOTONIC ACTIVITY OF 2,5-DIMETHOXYPHENYLIMIDAZO[2,1-B]-THIAZOLES [J].

ANDREANI, A ;

RAMBALDI, M ;

BONAZZI, D ;

BOSSA, R ;

GALATULAS, I .

ARCHIV DER PHARMAZIE, 1985, 318 (11) :1003-1008

[7] INOTROPIC 2-ARYLIMIDAZOL[1,2-A]PYRIMIDINES [J].

BARRACLOUGH, P ;

BLACK, JW ;

CAMBRIDGE, D ;

CAPON, E ;

COX, MR ;

FIRMIN, D ;

GERSKOWITCH, VP ;

GILES, H ;

GLEN, RC ;

HILL, AP ;

HULL, RAD ;

IYER, R ;

KETTLE, D ;

KING, WR ;

NOBBS, MS ;

RANDALL, P ;

SKONE, P ;

SMITH, S ;

VINE, SJ ;

WHARTON, CJ ;

WHITING, MV .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (03) :207-217

[8] UBER EINIGE AMINOALKOHOLE DER PYRIDYL- UND DIPYRIDYL-ATHANREIHE [J].

DORNOW, A ;

MACHENS, H ;

BRUNCKEN, K .

CHEMISCHE BERICHTE-RECUEIL, 1951, 84 (02) :147-150

[9] IMIDAZO[1,2-A]PYRIDINE ANTHELMINTIC AND ANTIFUNGAL AGENTS [J].

FISHER, MH ;

LUSI, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (09) :982-&

[10]

FRIZ L. POLO, 1963, FARM EDIZIONE SCI, V18, P972

← 1 →