MORPHINE POLYMERIC COPRECIPITATES FOR CONTROLLED-RELEASE - ELABORATION AND CHARACTERIZATION

被引：16

作者：

ALVAREZFUENTES, J ^{[1
]}

FERNANDEZAREVALO, M ^{[1
]}

HOLGADO, MA ^{[1
]}

CARABALLO, I ^{[1
]}

LLERA, JM ^{[1
]}

RABASCO, AM ^{[1
]}

机构：

[1] UNIV SEVILLA,FAC FARM,DEPT QUIM ORGAN & FARMACEUT,E-41012 SEVILLE,SPAIN

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 15期

关键词：

D O I：

10.3109/03639049409042646

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Coprecipitates of morphine were prepared by using Eudragit(R) L30D as a carrier in order to obtain controlled release dosage systems. Differential Scanning Calorimetry and IR, H-1- and C-13-NMR spectroscopies were applied in order to explain the mechanism of this interaction. The results obtained indicated that there was an intermolecular association between the polymer and the drug consisting in two different hydrogen bonds interactions. The proposed reaction involves coprecipitates having morphine contents greater than 50 %.

引用

页码：2409 / 2424

页数：16

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