COMPARATIVE EFFICACY OF A SINGLE ORAL DOSE OF ONDANSETRON AND OF BUSPIRONE AGAINST CISPLATIN-INDUCED EMESIS IN CANCER-PATIENTS

被引：14

作者：

ALFIERI, AB ^{[1
]}

CUBEDDU, LX ^{[1
]}

机构：

[1] CENT UNIV VENEZUELA, SCH PHARM, DEPT PHARMACOL, CARACAS, VENEZUELA

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 72卷 / 04期

关键词：

SEROTONIN; EMESIS; CISPLATIN; BUSPIRONE; ONDANSETRON; SEROTONIN RECEPTORS;

D O I：

10.1038/bjc.1995.452

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Buspirone, an agonist of the 5-HT1A subtype of serotonin receptors, has shown antiemetic activity in animal models. However, in cancer patients treated with cisplatin, ondansetron, given either i.v. (one 8-mg dose 30 min after cisplatin) or orally (one 16-mg dose at the end of cisplatin infusion) was superior (P<0.001) to buspirone (60 mg p.o. at the end of cisplatin and 60 mg p.o., 30 min later), in all parameters of antiemetic efficacy. These results are in favour of 5-HT3 receptors, but against the participation of 5-HT1A receptors in acute emesis associated with cisplatin chemotherapy.

引用

页码：1013 / 1015

页数：3

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