EFFECT OF THYROXINE AND CORTISOL ON SOME DEHYDROGENASES AND LYSOSOMAL ENZYMES ACTIVITIES IN AT PINEAL CULTURES

A histoenzymologic investigation was made concerning the effects of variable doses of thyroxine, cortisol, growth hormone, testosterone propionate and stilboestrol on some oxydo-reducing and lysosomal enzymes activity in rat pineal cell cultures. The thyroxine stimulated predominantly the enzymes of Krebs and Emhden-Meyerhoff cycles and the lipid metabolism. The cortisol stimulated the aryl-sulphatase only. No effect was shown by the pituitary growth and sex hormones. By means of hystoenzymologic techniques two pinealocytes types were in vitro identified: round (basophile) highly active cells and polyedric (chief) cells with lesser enzymatic activity. © 1968 Springer-Verlag.