NA+-DEPENDENT, ELECTRONEUTRAL L-ASCORBATE TRANSPORT ACROSS BRUSH-BORDER MEMBRANE-VESICLES FROM GUINEA-PIG SMALL-INTESTINE

被引:80
作者
SILIPRANDI, L
VANNI, P
KESSLER, M
SEMENZA, G
机构
[1] Laboratorium für Biochemie der E.T.H., CH-8092 Zürich
关键词
(Brush border vesicle; Guinea pig); Electroneutral transport; Heterologous inhibition; l-Ascorbate transport;
D O I
10.1016/0005-2736(79)90252-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In brush border vesicles from guinea pig small intestine l-ascorbate transport is Na+-dependent and electroneutral (in the presence of Na+, as shown by its lack of response to either positive or negative Δψ across the membrane). l-Ascorbate transporter has the kinetic characteristics of a mobile carrier (Km for l-ascorbate, 0.3 mM). d-Isoascorbate (erythorbate) seems to be another, but poorer, substrate of the same transporter. l-Ascorbate transport is subjected to heterologous inhibition by d-glucose. © 1979.
引用
收藏
页码:129 / 142
页数:14
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